Asante Kotoko left Accra on Thursday afternoon to play a combined side of Simba FC and Young Africans in a commemorative match in Tanzania.
The club departed from the Kotoka International Airport in Accra without their top scorer Ahmed Toure who is in Egypt for a medical.
Head coach Maxwell Konadu's strong 18-man squad included veteran Stephen Oduro and in-form striker Nathaniel Asamoah.
Rugged midfielder Yahaya Mohammed could not make the trip due to injury.
The team will transit in Cairo for four hours before landing in Dar-Es Salem.
The match will be played on Sunday 11 December at 11:00 GMT.
Kotoko last visited Tanzania in 2005 for pre-season under veteran trainer EK Afranie where they beat Simba FC 1-0 and drew 1-1 with Young Africans.
The trip is to honour the 50th Independence anniversary of the Eastern African country
Goalkeepers: Soulama Abdulai, Felix Annan
Defenders: Yaw Frimpong, Baba Rahman, Ohene Brenya, Amos Frimpong, Awal mohammd, Mohammed Sabato.
Midfielders: Frank Boateng, Afranie Yeboah, Daniel Nii Adjei, Michael Akuffo, David Offei, Stephen Oduro, Fatawu Mohammed.
Strikers: Kofi Nti Boakye, Nafiu Iddrisu, Nathaniel Asamoah