Asante Kotoko edged out of the league title race after losing to Bechem United on matchday 33 fixture at the Nana Fosu Gyabour Park on Sunday.
The Porcupine Warriors needed to win the game to push the league title decider to the final day of the season.
A first-half brace by Steven Owusu gave the Hunters a memorable 2-1 win in their penultimate game of what has been a weird season for them.
Sarfo Taylor got the consolation for Asante Kotoko which was his first goal of the season since joining the club in the second transfer window.
Bechem United were title contenders in the early stages but saw themselves needing three points against Kotoko to avoid a nerve-wracking final day.
A defeat would have seen them level on points with other relegation candidates, but they are now three points ahead, meaning a draw in their last match against Ebusua Dwarfs would be enough.
Watch highlights of the game below: