Ghanaian duo Jonathan Mensah and Lalas Abubakar were sent off in Columbus Crew 3-0 defeat to Philadelphia Union in the MLS on Wednesday night.
Mensah was shown a straight red for tackling an on-rushing Sapong in the 35th minute which resulted in a penalty.
Crew SC went down another man when defender Lalas Abubakar became tangled with Ilsinho and was ejected in the 76th minute with a second yellow card.
Compatriot Mohammed Abu replaced Justin Meram in the second half.